• Dr. Teresa Rispoli

Reverse Skin Aging and Get Youthful Skin with Red Light Therapy and Near-Infrared Light Therapy


Today, research into the power of red light to improve health and treat disease is really gaining momentum. We are learning that red and near-infrared light therapy can benefit virtually every system of the body and can even improve the way you look– it can help you to shed inches of fat, reduce the signs of aging, regrow hair, increase the results you get from your workouts, reduce pain, speed healing, boost hormonal health, and lower inflammation.

So now, let’s talk about the specific benefits of red and near-infrared light that have been shown in studies. Here are the major benefits that have been proven by scientific research for near-infrared and red light therapy: Reverse Skin Aging & Get Youthful Skin with Red Light/ Near-Infrared Light Therapy A wealth of human studies is proving near-infrared and red light therapy can reverse the signs of aging, repair damage from UV rays, and reduce the appearance of lines, wrinkles, and even hard to remove scars. Dozens of studies have shown that red and near-infrared light therapy can: · Reduce the signs of damage, DNA damage, (80) and aging from UV rays (81) · Reduce wrinkles (82) · Reduce color patches, hyperpigmentation, and skin discoloration (83) · Enhance collagen synthesis and collagen density (research has shown it can enhance production of collagen by 31% (84,85) · Accelerate repair in the epithelial layer of skin (86) · Combat other skin conditions like acne, keloids, vitiligo, burns, herpes virus sores, and psoriasis (87) · Speed wound healing by enhancing skin tissue repair and growth of skin cells (88) Slow Hair Loss and Re-Grow Hair with Near-Infrared and Red Light Therapy Near-infrared and red light therapy has proven to help women with alopecia to significantly regrow and thicken hair.89 Near-infrared and red light therapy has also proven to regrow hair in men with hair loss in several studies.(90,91,92,93,94) Reduce Cellulite with Near-Infrared and Red Light Therapy One study found that when near-infrared and red light therapy is combined with massage, it led to an astounding 71% reduction in cellulite! (95) Another study that assessed the use of near-infrared and red light therapy on skin health found that “91% of subjects reported improved skin tone, and 82% reported enhanced smoothness of skin in the treatment area.” (96) Speed Up Wound Healing with Near-Infrared and Red Light Therapy Near-infrared and red light therapy are fantastic for wound healing. Red/infrared light accomplishes this in several ways: · Cleaning up dead and damaged cells in skin (phagocytosis) · Increasing ATP in skin cells, giving cells more energy to heal themselves · Increasing the production of fibroblasts (98,99) · Increasing blood flow, supplying the wound more oxygen and nutrients needed for repair · Stimulating the production of collagen and the health of the extracellular matrix (100) · Stimulating lymph activity · Stimulating the formation of new connective tissue and blood capillaries on the surface of the wound. (101,102,103,104,105,106,107) Combat Fibromyalgia and Chronic Fatigue, and Increase Energy Levels with Near- Infrared and Red Light Therapy Studies show that red light therapy is also effective at restoring energy and vitality in persons suffering with fibromyalgia. Multiple studies have found that near-infrared and red light therapy offers: ● Enhanced quality of life for fibromyalgia patients ● Decreased pain ● Decreased muscle spasm ● Decreased morning stiffness ● Decreased total tender point number in fibromyalgia cases Research – including a very recent 2017 study – suggests that this therapy method is a safe and effective treatment for fibromyalgia.(110,111,112)


Fight Hashimoto’s Hypothyroidism with Near-Infrared and Red Light Therapy Several studies have shown profound benefits of near-infrared and red light therapy for autoimmune hypothyroidism. 1. A recent 2013 randomized, placebo-controlled study in hypothyroid patients demonstrated that in people who got near- infrared light therapy, thyroid function dramatically improved, and remarkably, that thyroid antibody (TPOAb) levels were massively reduced. Amazingly, 47% of patients were able to stop medication completely! 2. A 2010 study found that red light therapy helped 38 %of study participants reduce their hypothyroid medication dose, with a whopping 17 %being able to stop taking the medication altogether! (121) 3. A 1997 study done in Russia included some data on people with autoimmune hypothyroidism who underwent a thyroid surgery. They found that red/NIR light therapy improved thyroid hormone levels enough that they required, on average, roughly half as much thyroid hormone medication.(122) 4. A2003 study done in the Ukraine showed that red light therapy can decrease thyroid medication needs by 50-75% in people with postsurgical hypothyroidism.(123) 5. A 2010 Russian dissertation study gave red light therapy on the thyroid gland to a group of people with hypothyroidism and found that 17% of people could completely get off thyroid medication and 38% could decrease the dose by 25-50µg.(124) 6 · A 2014 study used the light therapy for 10 sessions with 347 women with subclinical hypothyroidism. At baseline, the average TSH (thyroid stimulating hormone) was 9.1 mIU/L. (Note: Higher TSH is a sign of hypothyroidism). After ten sessions of light therapy, the TSH was normalized in 337 (97%) of these women. Their TSH averaged at 2.2 mIU/L after just 10 light treatments. (125) Combat Inflammation (and Potentially Inflammation-Related Diseases) with Near- Infrared and Red Light Therapy

Red and near-infrared light therapy is highly effective in treating chronic inflammation. Since chronic inflammation is now being recognized as a major contributor to most chronic diseases from heart disease, depression, and cancer, to Alzheimer’s and chronic fatigue syndrome, this effect of red light therapy on inflammation is a very big deal. Many aging scientists now speak of “inflamm- aging”(145) — the concept that the genes and pathways that control inflammation may very well be the key drivers of aging and disease. Studies have even shown that red/NIR light therapy can have anti-inflammatory effects on par with non-steroidal anti-inflammatory drugs (NSAIDs),(149) which are the anti-inflammatory drugs routinely prescribed and typically, the over-the-counter drugs people buy when in pain. Combat Depression and Anxiety with Near-Infrared and Red Light Therapy A 2009 study took 10 patients with a history of major depression and anxiety (including PTSD and drug abuse) and gave them four weeks of treatments to the forehead with red/NIR light. Remarkably, by the end of the four-week study, 6 out of 10 patients experienced a remission of their depression, and 7 out of 10 patients experienced a remission of their anxiety.”(156) Though further research is needed, there have been 10 studies so far on the use of red and near-infrared light therapy to treat depression and anxiety related disorders with 9 of 10 studies yielding very positive results.(157,158,159,160,161,162,163,164)

Improve Cognitive Performance with Near-Infrared and Red Light Therapy In studies, researchers have found that transcranial near-infrared and red light therapy profoundly benefits the brain and cognitive performance.166 Research has also shown that transcranial near-infrared stimulation has been found to increase neurocognitive function in young healthy adults,(167) finding that it improved sustained attention and short-term memory retrieval in young adults, and improved memory in older adults with significant memory impairment at risk for cognitive decline.(168) Another study found near-infrared and red light therapy also increased executive cognitive function in young healthy adults, providing hope that further studies find that near-infrared and red light therapy may provide a hopeful treatment in the fight against Alzheimer’s disease, as well as prevention.169 Help Tendonitis with Near-Infrared and Red Light Therapy One of the most common uses for red and near-infrared therapy in clinics is for injuries and tendonitis. Because red light stimulates collagen production, speeds wound healing, and is highly anti-inflammatory, it has been shown to bring great relief to people suffering from tendinopathy and tendonitis. (170,171) A systematic review of the research concludes that near-infrared and red light therapy has proven highly effective in treating tendon disorders in all 12 studies conducted.(172) Improve Joint Health and Combat Arthritis with Near-Infrared and Red Light Therapy Numerous studies have shown that near-infrared and red light therapy can profoundly help people with osteoarthritis.(184,185,186,191) Improve Oral health with Near-Infrared and Red Light Therapy Red light therapy and near-infrared light therapy have proven to have numerous benefits for oral health and research in this area is booming right now. So far, studies indicate promising results for near-infrared and red light therapy, which has been shown to: · Combat viral and bacterial infections of the mouth; tonsillitis, herpes, cold sores. (200,201,202) · Facilitate tooth growth/tooth movement and reduce pain for individuals with corrective braces(204,205,206) · Help diabetics with gum problems and periodontal disease(207,208,209) · Reduce mouth pain(210) · Reduce thrush known as yeast in the mouth/candidiasis(211,212) · Improve tooth sensitivity(213,214) · Fight gum disease and gingivitis(215,216,217)

Decrease Pain with Near-Infrared and Red Light Therapy Here are several conditions where red/NIR light has proven effective: · Chronic neck pain(239 240) · Knee pain(241) · Fibromyalgia · Low back pain(242) · Chronic pain in the elbow, wrist and fingers(243) · Chronic joint disorders(244) · Sacroiliac joint pain(245) · Chronic tooth pain(246,247) · Osteoarthritic pain(248) · Tendinitis and myofascial pain(249) In a recent systematic review, researchers concluded that red light therapy has proven “beneficial for many individuals suffering from pain, regardless of the condition that is causing it.”(250) Fall Asleep Faster and Improve Sleep Quality Several studies in China have found that red/NIR light can increase melatonin and provide dramatic sleep benefits to people with insomnia.(295,296,297) · The first documented use of a similar intranasal light therapy device to directly observe melatonin level was conducted by Xu C et al in 2001. They treated 38 subjects that had insomnia with intranasal low level laser therapy once a day over 10 days. They found that serum melatonin had increased. · The same group of researchers further treated another group of 128 patients with insomnia and found that the polysomnogram (sleep study that includes data on brain waves as electrical activity) data had improved. · In 2006, Wang F et al reported that they had treated 50 patients with insomnia with intranasal low level laser therapy that is of similar specifications to Vielight’s laser device for 60 minutes per session. Each session was conducted once a day over between 10 to 14 days. They found that the condition had improved significantly in 41 (82%) of the cases, mild for 4 (8%) of the cases, and none for 5 (10%) of the cases. · Traditional Chinese Medicine practitioners often prescribe herbs as remedy for insomnia. This seems to help somewhat. Chen YM et al tested 90 patients and found that that the condition improved significantly for 40% of the cases, mild for 37.5% and none for 22.5% of the cases. In the group that added the extra element of the intranasal low level laser therapy, the improvement in the number of positive results were significantly more impressive. 78% of the patients experienced significant improvement, 20% mild and 2% none.(298,299,300,301) Improve Brain Health, and Slow Progression of Alzheimer’s and Parkinson’s Disease with Near-Infrared and Red Light Therapy Recent studies have now found that near-infrared and red light therapy may significantly slow the progression of Alzheimer’s and Parkinson’s disease.(309,310) Red and near-infrared light have been shown to:(312,313,314,315,316) · Benefit cognitive performance and memory · Improved mitochondrial function of brain cells · Have a protective effect on neurons · Improve cellular repair of neurons

· Increase brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) · Decrease brain inflammation (decreased pro-inflammatory cytokines and increased

anti-inflammatory cytokines)

Enhance Muscle Gain, Strength, Endurance, and Recovery with Near-Infrared and Red Light Therapy Red/NIR light with exercise makes a potent combination. Not only does red/NIR light help you recover faster, it seems to amplify everything that happens with exercise – increased muscle gain, fat loss, performance, strength, and endurance. How does red and near-infrared light affect muscles – what is it actually doing to cause these benefits? It works through several important mechanisms in the body: · Red and near-infrared light help promote the production of internal antioxidants by your cells, which prevents oxidative stress and damage to the muscle tissue (when light is applied before exercise).(340,341) · Red and near-infrared light help reduce inflammation that will lead to cellular damage (and fatigue) in the muscle tissue as well. (342,343) · Protect damaged muscles from secondary damage from further exercise. · Pre-conditioning: By using the light prior to exercise, it creates a “pre-conditioning” effect where the muscle cells suffer less damage from the exercise, as well as display higher strength/stamina in subsequent exercise following the initial bout of exercise. · Red and near-infrared light decrease lactic acid production by muscles. · Red and near-infrared light improve mitochondrial function during exercise. · Increases acetylcholine receptors on muscles (this is the neurotransmitter released from nerve cells that stimulates muscle contraction). · Red and near-infrared light increase the production of specific types of heat shock proteins that protect cells from oxidative damage, stress, and apoptosis (early cell death).(344) · Red and near-infrared light also enhance muscle growth, as well as increasing strength significantly.(345) · Red and near-infrared light therapy promotes the development of muscle stem cells, myosatellite cells, which develop into specific varying types of muscles. · Red and near-infrared light also have the profound benefit of increasing mitochondrial adaptations and mitochondrial biogenesis (the creation of new mitochondria) following exercise.(346) Increase Fat Loss (And Burn Off Stubborn Fat) with Near-Infrared and Red Light Therapy In studies, near-infrared and red light therapy have helped shave an entire 3.5 to 5.17 inches off waist and hip circumference by reducing the fat mass layer in just four weeks of use. (359,360) In another study of 86 individuals using red light therapy at 635 nm for 20 minutes every other day for two weeks, study participants lost 2.99 inches across all body parts — yes, 3 inches — in just 14 days of red light therapy.(362) That said, I am not a strong advocate of trying to use red/NIR light therapy alone to cause fat loss. Where I believe red/NIR light therapy really shine (forgive the pun) is when combined with exercise.

Some research shows that near-infrared light therapy can dramatically enhance — nearly double — fat loss from exercise, as compared to people doing just the exercise routine without the NIR light therapy.(363)

In addition, the group using the NIR light therapy in tandem with exercise saw nearly double the improvements in insulin resistance!364

The above graph shows the differences in reductions in body weight, body fat, insulin levels, and insulin resistance (IR) from either NIR light therapy (ET-PHOTO) vs. sham/placebo light therapy (ET-SHAM). As you can see, exercising with NIR light nearly doubled the loss of body fat and nearly doubled the improvement in insulin resistance.

Guide to Red Light Therapy Treatments LipoMelt Ultimate Light treatments should be done 2 to 3 times weekly You Want Therapeutic Wavelengths that Achieve Real Results Again, not all wavelengths are equal — nor all devices. Out LipoMelt Ultimate Device has wavelengths in the proven therapeutic ranges for both. Based on the bulk of the research, you want: ● 630-680nm (the optimal healing spectrum of red light) ● 800 to 880nm (the optimal healing spectrum of near-infrared) ● or a combination of both

How Big is the Light and How Much of Your Body Can It Treat at Once Most near-infrared and red light therapy devices have a very small treatment area capability. Most handheld devices and red lights sold online as skin improving/anti-aging devices offer about 10mW/cm2 (and many of them offer far less than even that!) and only treat about a 5-10 square inch area, meaning you’d have to use the device for 30-60 minutes to cover a significant area of your body. But if you get a device with a high power output that also treats a large area at once, that’s where the magic is. So again, it can basically function the same as a light that is 3 times the physical size (i.e. a light that is the size of your entire body). Having a high-power light that is large enough in size allows you to treat large areas of your body at once in just 25 minutes. You can treat an area like the face, the whole torso or legs, or even do multiple parts of the body and effectively, the entire body, in just a 25 minutes! What Do You Want to Achieve Using Red Light Therapy? Our LipoMeltTherapy Light Pads can be used for most purposes and for most people, the best choice is a combination of the 660nm and 850nm LEDs in a large LED panel that will treat a large area of the body at once. This option is best because it works for basically any and all purposes you could possibly want it for. A combined near-infrared and red light therapy device offering both 660nm and 850nm will allow you to do anything you want on any given day – whether anti-aging treatments on your skin, or healing an injury or lower back pain, or muscle recovery and fat reduction.

If you’re using light on the brain specifically – for either a brain health issue or to improve mood or cognitive function – it’s important to get a light with near-infrared, not just red light. Research has shown that near-infrared is more effective in penetrating the skull than red light (which has minimal to no penetration of the skull), so this is ideal for the brain. Final Words If all of the complexity and science talk has you feeling overwhelmed, I want to end with some simplicity. I’ve tried to cover the nuances of the science on this topic in this book, but I don’t want you to get so caught up in all the details that you feel overwhelmed and confused on how to get started and actually do a red/NIR light therapy session. So let me summarize the practical aspects of all this in a very simple way: Make an appointment at Complete Health in Agoura Hills California Call 818-707-3126 Choose one of 3 options 1. LipoMelt whole body. 2. Or if you want to include the face or brain choose Lipomelt whole body and face. 3. If you are interested in wrinkle reduction and face tightening choose Ultimate Light LED Skin Tightening Facial Treatment That’s it. It’s really that simple. After you sign up for one of these lights treatments, you can immediately start using it to: ● Increase your energy ● Make your skin healthier and get rid of cellulite ● Speed up fat loss ● Improve muscle recovery and athletic performance ● Improve mood and cognitive function ● Increase muscle size and strength ● Speed healing from injury ● Improve metabolic and hormonal health You now know everything you need to know to start using this powerful technology. Now go start using it and taking your health, body and energy to new heights!


About the Author Teresa Rispoli, DCN, L.Ac., Ph.D. is the founder and director of Complete Health, a Holistic Wellness Center & Alternative Med Spa located in Agoura Hills, California. And is the founder of Functional Nutritionist Academy, where she provides you with online Functional Nutrition lessons and certification. https://functionalnutritionistacademy.com/

She is highly recognized Functional Nutritionist with a triple PhD. She also holds a Doctor in Naturopathy, Doctor of Clinical Nutrition, Doctor of Philosophy and holds a Master in Oriental Medicine, and is a Master Herbalist and licensed Acupuncturist and Esthetician. She has been practicing natural medicine for over 27 years in the same location in Agoura Hills California. She believes in patient-centered, individualized holistic approach, and getting to the root of the problem not just treating symptoms. This practice is known as "Functional Medicine" (root resolution medicine). She takes in to account diet, your microbiome, stress, exercise, environmental toxins, with emerging science, such as genomics. She believes the Gut is at the center of most chronic health issues and strives to identify and remove triggers, toxins and infections that cause inflammation and imbalances in the body which produce symptoms such as weight gain, fatigue, insomnia, anxiety, acne, headaches, brain fog and chronic illness. She will identify your triggers, address and control your symptoms. She specializes in preventative, functional, integrative nutrition, restoring health and well-being by restoring balance to your digestive, immune system, hormones, methylation, energy, weight control, cognition, mood, longevity. Her methods involve detoxifying, rebuilding & balancing the body through diet and lifestyle modifications, nutrition, acupuncture, and provides comprehensive and personalized consultations in natural hormone balancing, including sex hormones, thyroid hormones, and adrenal hormones. She recommends supplementation and nutritional support for gut issues, allergies, intolerances, fatigue, high cholesterol, hypertension, metabolic syndrome, diabetes, weight issues, autoimmune illness, and disease of aging to mention a few. By utilizing cutting edge technology and Functional Specialty Laboratory Testing she can get to the root of your health concerns fast with very little cost to you! In her 27 years of practice, Dr. Rispoli has been successful in weight-loss programs, mitigating food sensitivities,allergies, intolerances, anxiety, arthritis, asthma, chronic fatigue, depression, gut and digestive disorders, female disorders, environmental illness, headaches, menopause, PMS, pain, and much more. You may contact Dr. Rispoli at (818) 707-3126 to schedule an appointment in person or over the phone.


REFERENCES: 3 Freitas de Freitas et al. (2016) Proposed Mechanisms of Photobiomodulation or Low Level Light Therapy 5 https://www.ncbi.nlm.nih.gov/pubmed/29565713 6 http://sunlightinstitute.org/new-research-sheds-more-light-on-parkinsons-disease/ 7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808871/ 8 http://n.neurology.org/content/early/2018/03/07/WNL.0000000000005257 9 https://academic.oup.com/jnci/article/97/3/161/2544132 10 https://www.ncbi.nlm.nih.gov/pubmed/23094923 11 https://www.sciencedirect.com/science/article/pii/S2214623714000386 12 https://www.ejcancer.com/article/S0959-8049(06)00482-5/abstract 13 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086738/ 14 https://www.ncbi.nlm.nih.gov/pubmed/28009891 15 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086738/ 16 https://www.ncbi.nlm.nih.gov/pubmed/28009891 17 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086738/ 18 https://www.medscape.com/viewarticle/860805 19 https://www.ncbi.nlm.nih.gov/pubmed/24697969 20 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739143/ 21 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/ 22 https://hub.jhu.edu/2012/11/14/light-exposure-depression/ 23 https://www.nature.com/articles/ijo2015255 24 https://academic.oup.com/aje/article/180/3/245/2739112 25 https://academic.oup.com/edrv/article/35/4/648/2354673 26 https://www.sciencedaily.com/releases/2017/07/170728121414.htm 27 https://hub.jhu.edu/2012/11/14/light-exposure-depression/ 32 Hamblin, M. (2008). The role of nitric oxide in low level light therapy. https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapy 33 Hamblin, M, et al. (2018). Low-level light therapy: Photobiomodulation. Society of Photo-Optical Instrumentation Engineers (SPIE). 34 Hamblin, M. (2008). The role of nitric oxide in low level light therapy. https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapy 80 Lau et al. The effects of low level laser therapy on irradiated cells: a systematic review 81Jiang, M. et. al. (2017). A prospective study of the safety and efficacy of a combined bipolar radiofrequency, intense pulsed light, and infrared diode laser treatment for global facial photoaging. Lasers in Medicine and Science, 32(5):1051- 1061. 82Kim, Hee-Kyong. (2017). Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheek. Journal I Physical Therapy and Science, 29(2): 290–294. 83Pinar, Avci. Low-level laser (light) therapy (red and near-infrared light) in skin: stimulating, healing, restoring. SCMS, 32(1): 41-52. 84Barolet, D. (2009). Ba Regulation of Skin Collagen Metabolism In VitroUsing a Pulsed 660 nm LED Light Source: Clinical Correlation with a Single-Blinded Study, Journal of Investigative Dermatology, 129(12): 2751-2759. 85Wunsch, A. (2014). A Controlled Trial to Determine the Efficacy of Red and near-infrared light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase. Photomedicine in Lasers and Surgery, 32(2): 93–100. 86 Fabiana do Socorro da Silva Dias Andrade et al. (2014) Effects of low-level laser therapy on wound healing 87Jiang, M. et. al. (2017). A prospective study of the safety and efficacy of a combined bipolar radiofrequency, intense pulsed light, and infrared diode laser treatment for global facial photoaging. Lasers in Medicine and Science, 32(5):1051- 1061.


88 Barolet, D. et. al. (2016). Accelerating Ablative Fractional Resurfacing Wound Healing Recovery by Photobiomodulation, Current Dermatology Reports, 5(3): 232-38. 89Lanzafame, R. J. et. al. (2014). The growth of human scalp hair in females using visible red light laser and LED sources. Lasers in Surgery and Medicine, 46(8): 601-607. 90 Wiley, A. et. al. Hair stimulation following laser and intense pulsed light photo-epilation: Review of 543 cases and ways to manage it. Lasers in Surgery and Medicine, 39(4): 297-301. 91 Kim, S.S. et. al. (2007).Phototherapy of androgenetic alopecia with low level narrow band 655-nm red light and 780-nm infrared light. J of American Academy of Dermatology. American Academy of Dermatology 65th Annual Meeting. p. AB112. 92 Jimenez JJ., et al. (2014) Efficacy and safety of a low-level laser device in the treatment of male and female pattern hair loss: a multicenter, randomized, sham device-controlled, double-blind study. 93 Dodd EM., et al. (2017) Photobiomodulation therapy for androgenetic alopecia: A clinician's guide to home-use devices cleared by the Federal Drug Administration. 94 Adil A., et al. (2017) The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis 95 Gold et al. (2011). Reduction in thigh circumference and improvement in the appearance of cellulite with dual- wavelength, low-level laser energy and massage. 96 Avci et al. (2013). Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. 98 Balboni, G.C., et. al. (1986) Effects of He-Ne/I.R. lasers irradiation on two lines of normal human fibroblasts in vitro. Arch Italian journal of Anatomy and Embryology, 91:179–188. 99 Bosarta, M., et. al. (1984) In vitro fibroblast and dermis fibroblast activation by laser irra- diation at low energy. Dermatologica, 168:157–162 100Lam, T.S., et. al. (1986) Laser stimulation of collagen synthesis in human skin fibroblast cultures. Lasers in the Life Sciences, 1:61–77 101Trelles, M. A. et. al. (2006). Red light-emitting diode (LED) therapy accelerates wound healing post-blepharoplasty and periocular laser ablative resurfacing. Journal of Cosmetic Laser Therapy, 8(1): 39-42 102Barolet, D. et. al. (2016). Accelerating Ablative Fractional Resurfacing Wound Healing Recovery by Photobiomodulation, Current Dermatology Reports, 5(3): 232-38. 103de Abreu Chaves, M. E. et. al. (2014). Effects of low-power light therapy on wound healing: LASER x LED*. Anais Brasileiros de Dermatologia. 89(4): 616–623. 104de Lima, F. (2014). Use alone or in Combination of Red and Infrared Laser in Skin Wounds. Lasers in Medicine and Science, (2): 51–57. 105Mester, E. et. al. (1978). Stimulation 532 of wound healing by means of laser rays. Acta Chir Acad Sci Hung 19:163– 170 106 Mester, E, et. al. (1985). The biomedical effects of laser application. Lasers in Surgery and Medicine, 5:31–39. 107 Kana, J. S., et. al. (1981). Effect of low-power density laser radiation on healing of open skin wound in rats. Archives in Surgery, 116:293–296. 110 Gur, A. (2002). Efficacy of low power laser therapy in fibromyalgia: a single-blind, placebo-controlled trial. Lasers in Medical Science, 17(1): 57-61. 111 Ruaro, J. A. (2014). Low-level laser therapy to treat fibromyalgia. Lasers and Medicine in Science, 29(6):1815-9. 112 Da Silva, M. et al. (2017). Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment. Lasers in Medical Science. 121 Heiskanen V. “Valtsu” (205). Hypothyroidism: Could it be treated with light? Valtsu’s. 122 Heiskanen V. “Valtsu” (205). Hypothyroidism: Could it be treated with light? Valtsu’s. 123 Heiskanen V. “Valtsu” (205). Hypothyroidism: Could it be treated with light? Valtsu’s. 124 Heiskanen V. “Valtsu” (205). Hypothyroidism: Could it be treated with light? Valtsu’s. 125 Heiskanen V. “Valtsu” (205). Hypothyroidism: Could it be treated with light? Valtsu’s. 145 Franceschi C (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. https://www.ncbi.nlm.nih.gov/pubmed/24833586 149 Cotler at al. (2015). The Use of Low Level Laser Therapy (LLLT) For Musculoskeletal Pain. 156 https://www.ncbi.nlm.nih.gov/pubmed/19995444 157Disner, S. G. (2016). Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms. Sep-Oct;9(5):780-7. 158Mohammed, H. S. (2016). Transcranial low-level infrared laser irradiation ameliorates depression induced by reserpine in rats. Lasers in Medical Science, 31(8):1651-1656.


159Xu, Z. (2017). Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice. Molecular Neurobiology, 54(6):4551-4559. 160 Salehpour, F. (2016). Therapeutic effects of 10-HzPulsed wave lasers in rat depression model: A comparison between near-infrared and red wavelengths. Lasers in Surgery and Medicine, 48(7):695-705. doi: 10.1002/lsm.22542. Epub 2016 Jul 1. 161Wu, X. (2012). Pulsed light irradiation improves behavioral outcome in a rat model of chronic mild stress. Lasers in Surgical Medicine, 44(3): 227-32. 162Tanaka, Y. (2011). Infrared radiation has potential antidepressant and anxiolytic effects in animal model of depression and anxiety. Brain Stimulation, 4(2):71-6. 163Schiffer, F. (2009). Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety. Behavioral Brain Function, 5:46. 164 Henderson TA., et al. (2017) Multi-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Study. 166Hwang, J. (2016). Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise. Lasers in Medical Science, 31(6):1151-60. 167Blanco, N. (2017). Improving executive function using transcranial infrared laser stimulation. Journal of Neuropsyhology, 11(1): 14–25. 168Vargas, E. (2017). Beneficial neurocognitive effects of transcranial laser in older adults. Lasers in Medical Science, 32(5):1153-1162. 169Blanco, N. (2017). Improving executive function using transcranial infrared laser stimulation. Journal of Neuropsyhology, 11(1): 14–25. 170Tumilty, S. (2010). Low level laser treatment of tendinopathy: a systematic review with meta-analysis. Photomedicine and Laser Surgery, 28(1):3-16. 171Bjordal, J.M., (2006). A randomised, placebo controlled trial of low level laser therapy for activated achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations. British Journal of Sports Medicine, 40:76–80. 172 Tumilty, S. (2010). Low level laser treatment of tendinopathy: a systematic review with meta-analysis. Photomedicine and Laser Surgery, 28(1):3-16. 184 Hegedus et al. (2009). The Effect of Low-Level Laser in Knee Osteoarthritis: A Double-Blind, Randomized, Placebo- Controlled Trial. 185 Hamblin, M. et al. (2013). Can osteoarthritis be treated with light? Arthritis Research & Therapy. https://arthritis-research.biomedcentral.com/articles/10.1186/ar4354 186 Taheri et al. (2014). The effect of low-level laser therapy on knee osteoarthritis: prospective, descriptive study. 191 Hamblin, M. et al. (2013). Can osteoarthritis be treated with light? Arthritis Research & Therapy. https://arthritis-research.biomedcentral.com/articles/10.1186/ar4354 200Zohreh, V. (2007). Application Of Low Level Laser Therapy (Red and near-infrared light) In Treatment Of Chronic Tonsillitis: (Case Series) 201Aggarwal, H. (2014). Efficacy of Low-Level Laser Therapy in Treatment of Recurrent Aphthous Ulcers – A Sham Controlled, Split Mouth Follow Up Study. Journal of clinical and diagnostic research : JCDR. 8(2): 218–221 202 Carvalho, D. (2011). Herpes simplex recorrente: laser terapia como m todo alternativo para. Revista da Sociedade Brasileira de Medicina Tropical, 44(3):397-399. 204Genc, G. (2013). Effect of low-level laser therapy (red and near-infrared light) on orthodontic tooth movement. Lasers in Medical Science, 28(1):41-7. 205 Seifi, M. (2014). Effects of low-level laser therapy on orthodontic tooth movement and root resorption after artificial socket preservation. Dental research journal, 61(6): 206 Yassaei, S. (2013). Effect of Low Level Laser Therapy on Orthodontic Tooth Movement: A Review Article. Journal of Dentistry (Tehran). 10(3): 264–272. 207Basso, F. G. (2011). In Vitro effect of low-level laser therapy on typical oral microbial biofilms. Brazilian Dental Journal, 22(6):502-10. 208Asnaashari, M. (2016). A comparison of the antibacterial activity of the two methods of photodynamic therapy (using diode laser 810 nm and LED lamp 630 nm) against Enterococcus faecalis in extracted human anterior teeth. Photodiagnosis and Photodynamic Therapy, 13: 233-237. 209Rios, A. (2011). Evaluation of photodynamic therapy using a light-emitting diode lamp against Enterococcus faecalis in extracted human teeth. Journal of Endocrinology, 37(6): 856-9.


210Aggarwal, H. (2014). Efficacy of Low-Level Laser Therapy in Treatment of Recurrent Aphthous Ulcers – A Sham Controlled, Split Mouth Follow Up Study. Journal of clinical and diagnostic research : JCDR. 8(2): 218–221 211Maver-Biscanin, M. (2005). Effect of Low-Level Laser Therapy on Candida albicans Growth in Patients with Denture Stomatitis. Photomedicine and Laser Surgery, 23(3): 328-332. 212 Teichert, M.C., et. al. (2002). Treatment of oral candidiasis with methylene blue-mediated photodynamic therapy in an immunodeficient murine model. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, And Endodontics, 93(2):155-60. 213Gerschman, J. A. (1994). Low level laser therapy for dentinal tooth hypersensitivity. Australian Dental Journal, 39(6):353-7. 214Orhan, K. (2011). Low-level laser therapy of dentin hypersensitivity: a short-term clinical trial. Lasers in Medical Science, 26(5): 591-8. 215 Vieru, D. (2017). Low Level Laser Therapy In The Treatment Of Periodontal Disease. Laser Therapy, 16(4): 199-206. 216Obradovic, R. (2012). Low-Level Lasers as an Adjunct in Periodontal Therapy in Patients with Diabetes Mellitus. Diabetes Technology and Therapy,14(9): 799–803. 217 Vieru et al. (2007). Low level laser treatment in Periodontal Disease. 239Kingsley, J. D. (2014). Low-level laser therapy as a treatment for chronic pain. Fronteirs in Physiology, 5: 306. 240 https://www.sciencedirect.com/science/article/pii/S0304395906002880 241Kingsley, J. D. (2014). Low-level laser therapy as a treatment for chronic pain. Fronteirs in Physiology, 5: 306. 242 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704537/ 243Okuni, I. (2012). Low Level Laser Therapy (Red and near-infrared light) for Chronic Joint Pain of the Elbow, Wrist and Fingers, Laser Therapy, 21(1): 33–37. 244 https://www.journalofphysiotherapy.com/article/S0004-9514(14)60127-6/abstract 245Ohkuin, I. (2011). Low level laser therapy (red and near-infrared light) for patients with sacroiliac joint pain. Laser Therapy, 20(2):117-21. 246Arslan, H. (2017). Effect of Low-level Laser Therapy on Postoperative Pain after Root Canal Retreatment: A Preliminary Placebo-controlled, Triple-blind, Randomized Clinical Trial. Journal of Endocrinology, [Epub] 247Alayat, M. S. (2017). Efficacy of Multiwave Locked System Laser on Pain and Function in Patients with Chronic Neck Pain: A Randomized Placebo-Controlled Trial. Photomedicine in Laser Surgery, 35(8): 450-455. 248 Dima, R. (2017). Review of Literature on Low-level Laser Therapy Benefits for Nonpharmacological Pain Control in Chronic Pain and Osteoarthritis. Alternative Therapy in Health and Medicine. 249 https://www.jstage.jst.go.jp/article/islsm/14/0_Pilot_Issue_2/14_0_Pilot_Issue_2_0_79/_article/-char/ja/ 250Kingsley, J. D. (2014). Low-level laser therapy as a treatment for chronic pain. Fronteirs in Physiology, 5: 306. 295 Xu C, Wu Z, Wang L, Shang X, Li Q. 2002. The effect of endonasal low energy He-Ne laser treatment on insomniaon on sleep EEG. Prac J Med Pharm. 19(6): 407-408 (in Chinese). 296 Wang F. 2006. Therapeutic effect observation and nurse of intranasal low intensity laser therapy on insomnia. Journal of Community Medicine. 4(3): 58 (in Chinese). 297 https://onlinelibrary.wiley.com/doi/full/10.1002/jbio.201700282 298 http://www.mediclights.com/wp-content/uploads/2012/08/Natural-treatment-for-insomnia-and-sleep-disorder-08- 12.pdf 299 Xu C, Wu Z, Wang L, Shang X, Li Q. 2002. The effect of endonasal low energy He-Ne laser treatment on insomniaon on sleep EEG. Prac J Med Pharm. 19(6): 407-408 (in Chinese). 300 Wang F. 2006. Therapeutic effect observation and nurse of intranasal low intensity laser therapy on insomnia. Journal of Community Medicine. 4(3): 58 (in Chinese). 301 https://onlinelibrary.wiley.com/doi/full/10.1002/jbio.201700282 309Johnstone, D. et. al. (2015). Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease. Frontiers in Neuroscience, 9: 500. 310 Fannie Darlot,Ph.D., et al. (2015) Near-infrared light is neuroprotective in a monkey model of Parkinson disease 312 Hamblin, M, et al. (2018). Low-level light therapy: Photobiomodulation. Society of Photo-Optical Instrumentation Engineers (SPIE). 313 Meng, C. et al. (2013). Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease. The Journal of Neuroscience. 314 Johnstone, D. et al. (2015). Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease. Frontiers in Neuroscience.



315 de la Torre, JC. (2017). Treating cognitive impairment with transcranial low level laser therapy. Journal of Photochemistry and Photobiology.

316 Hamblin, M. (2016). Shining light on the head: Photobiomodulation for brain disorders. BBA Clinical.

340Avni, D., et. al. (2005). Protection of skeletal muscles from ischemic injury: low-level laser therapy increases antioxidant activity. Photomedicine and Laser Surgery, 23:273–277.

341 Rizzi, C.F., et al. (2006). Effects of low-level laser therapy (red and near-infrared light) on the nuclear factor (NF)- kappaB signaling pathway in traumatized muscle. Lasers in Surgery and Medicine, 38: 704–713.

342 Bjordal, J.M., (2006). A randomised, placebo controlled trial of low level laser therapy for activated achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations. British Journal of Sports Medicine, 40:76–80.

343 Aimbire, F., et al. (2006). Low-level laser therapy induces dose-dependent reduction of TNFalpha levels in acute inflammation. Photomedicine in Laser Surgery, 24:33–37.

344 De Almeida, et al. (2012). Red (660 nm) and infrared (830 nm) low-level laser therapy in skeletal muscle fatigue in humans: what is better? Lasers in Medical Science.

345Halliwell, B. Free radicals in biology and medicine. Oxford: Oxford University Press; 2000.

346 Sene-Fiorese, M. et al. (2015). The potential of phototherapy to reduce body fat, insulin resistance and "metabolic inflexibility" related to obesity in women undergoing weight loss treatment. Lasers in Surgery and Medicine, Oct;47(8):634-42.

359 Jackson, R.F., et. al. (2009). Low-level laser therapy as a non-invasive approach for body contouring: A randomized, controlled study. Lasers in Surgery and Medicine, 41(10):799–809.

360 Jackson, R.F., et. al. (2012). Application of low-level laser therapy for noninvasive body contouring. Lasers in Surgery and Medicine, 44(3):211–217

362McRae, E. et. al. (2013). Independent evaluation of low-level laser therapy at 635 nm for non-invasive body contouring of the waist, hips, and thighs. Lasers in Surgery and Medicine.

363 Suppversity.(2015) Phototherapy Doubles Fat Loss (11 vs. 6%) & Improvements in Insulin Sensitivity (40 vs. 22%) and Helps Conserve Lean Mass in Recent 20 Weeks 'Exercise for Weight Loss Trial'

364 Suppversity.(2015) Phototherapy Doubles Fat Loss (11 vs. 6%) & Improvements in Insulin Sensitivity (40 vs. 22%) and Helps Conserve Lean Mass in Recent 20 Weeks 'Exercise for Weight Loss Trial'

385 https://www.selfhacked.com/blog/interview-with-dr-michael-hamblin-harvard-professor-and-infrared-therapy-expert/

386 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568598/

 FUNCTIONAL  ALTERNATIVE HEALING
SPECIALIST 

  • Grey Facebook Icon
  • Grey Twitter Icon
  • Grey Instagram Icon

Dr. Teresa Rispoli

Tel: 818.707.3126

28247 Agoura Road

Agoura HIlls, CA 91301

  • White Facebook Icon
  • White Twitter Icon
  • White Instagram Icon

BY Teresa Rispoli